Sevrage

Glossary

NIV:	Non-Invasive Ventilation
COPD:	Chronic Obstructive Pulmonary Disease

Compendium

Compendium of Evidence 5.0

Weaning Begins with Intubation

The process of weaning from mechanical ventilation technically begins with intubation. Metaanalyses have shown that weaning makes up approx. 50% of the total time on mechanical ventilation. In certain patient groups (e.g., COPD) this proportion is even higher. During this time the lung continues to be damaged! In addition, a much greater oxygen demand is coupled with a weakened breathing musculature during weaning, increasing the risk of exhaustion.

The iLA Membrane Ventilator® takes over the majority of the work of breathing and thus enables a reduction in oxygen demand, avoiding exhaustion. An increase in the weaning success rate is the expected result.

Important therapeutic considerations in weaning are:

• Wean from the ventilator first, then from the iLA Membrane Ventilator®
• Use standardised protocols
• Strive for the earliest possibile induction of spontaneous breathing or pressure-assisted ventilation
• Wean with the support of non-invasive ventilation (NIV)
• Reduce sedation (Wake-up regime)

A key factor is the implementation of standardized weaning protocols, which are recommended as Class 1A evidence by the Surviving Sepsis Campaign in international guidelines. The following algorithm may serve as an example.